| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Spermatogenic Dysfunction in Azoospermic Japanese Men Caused by Y Chromosome Microdeletions |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Male infertility |
| キーワード |
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主題Scheme |
Other |
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主題 |
Azoospermia |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Testicular sperm extraction |
| キーワード |
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主題Scheme |
Other |
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主題 |
Y chromosome |
| キーワード |
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主題Scheme |
Other |
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主題 |
Y microdeletions |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Iwahata, Toshiyuki
Kobori, Yoshitomo
Shimomura, Yukihito
Suzuki, Keisuke
Shin, Takeshi
Song, Shigehiro
Okada, Hiroshi
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| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属 |
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Department of Urology, Dokkyo Medical University Koshigaya Hospital |
| 書誌情報 |
Dokkyo Journal of Medical Sciences
巻 44,
号 2,
p. 151-155,
発行日 2017-07-25
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| 要旨 |
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内容記述タイプ |
Other |
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内容記述 |
Genetic factors are responsible for approximately 15％ of male infertility. The azoospermia factors AZFa, AZFb（P5/proximal P1）, and AZFc（b2/b4） present on Yq are most important for spermatogenesis. Here,
we evaluated frequencies of microdeletions of AZFa, AZFb, AZFc in azoospermia due to spermatogenic
dysfunction in the Japanese population. The overall prevalence of Y chromosome microdeletions in infertile
men was 8.1％（79/980）. The prevalence of Y chromosome microdeletions in AZFa, AZFb, AZFabc, AZFbc （P5/distal P1 or P4/distal P1） and AZFc was 0.1％ , 0.8％ , 0.7％ , 2.0％ and 4.4％ , respectively. Microdissection for testicular sperm extraction failed in all patients with microdeletion in AZFa, AZFb, AZFabc, and AZFbc, although sperm could be retrieved in 28/43 patients with AZFc deletions（62.2％）. The presence of an AZFc deletion was associated with significantly better sperm retrieval than the 33.0％ retrieval rate in idiopathic non-deleted azoospermic men undergoing microdissection for testicular sperm
extraction at our institution during the study period. We conclude that Y chromosome microdeletion testing is essential for genetic and preoperative counseling in these patients. |
| 記事種別 |
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Original |
| 出版者 |
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出版者 |
獨協医学会 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00629581 |
| 表示順 |
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4 |
DJMS-44-2-Iwahata-本文 (64.2 kB)
