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Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study
https://dmu.repo.nii.ac.jp/records/2420
https://dmu.repo.nii.ac.jp/records/2420e270ba9a-93f8-4a12-8bf1-b4d83684d4d3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-47-3-Akutsu-本文 (337.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| タイトル | ||||||||||||||||
| タイトル | Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Tissue remodeling | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Histopathology | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Computed tomography score | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Polyp score | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Olfaction recognition threshold | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Akutsu, Makoto
× Akutsu, Makoto
× Kanaya, Hiroaki
× Kashiwagi, Takashi
× Tsunemi, Yasuhiro
× Haruna, Shin-ichi
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| 著者所属(英) | ||||||||||||||||
| en | ||||||||||||||||
| Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | ||||||||||||||||
| 著者所属(英) | ||||||||||||||||
| en | ||||||||||||||||
| Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | ||||||||||||||||
| 著者所属(英) | ||||||||||||||||
| en | ||||||||||||||||
| Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | ||||||||||||||||
| 著者所属(英) | ||||||||||||||||
| en | ||||||||||||||||
| Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | ||||||||||||||||
| 著者所属(英) | ||||||||||||||||
| en | ||||||||||||||||
| Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | ||||||||||||||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences 巻 47, 号 3, p. 125-136, 発行日 2020-10-25 |
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| 要旨(英) | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Background：Eosinophilic chronic rhinosinusitis（ECRS） is an intractable subtype of chronic rhinosinusitis（CRS）, which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive （MMP-8＋）neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS. Methods：Nasal polyps （NPs）in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8＋ neutrophils in NPs were evaluated in combination with histological and clinical parameters. Results：MMP-8＋ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8＋ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group；however, the percentage of MMP-8＋ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8＋ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8＋ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group. Conclusions：This study suggests that MMP-8＋ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8＋neutrophils might become a candidate of nasal therapeutic target for patients with ECRS. |
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| 記事種別 | ||||||||||||||||
| Original | ||||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | 獨協医学会 | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 03855023 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA00629581 | |||||||||||||||
