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Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis :a Clinico-pathological Study
https://dmu.repo.nii.ac.jp/records/2420
https://dmu.repo.nii.ac.jp/records/2420e270ba9a-93f8-4a12-8bf1-b4d83684d4d3
名前 / ファイル | ライセンス | アクション |
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DJMS-47-3-Akutsu-本文 (337.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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タイトル | ||||||
タイトル | Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis :a Clinico-pathological Study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tissue remodeling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Histopathology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Computed tomography score | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyp score | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Olfaction recognition threshold | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Akutsu, Makoto
× Akutsu, Makoto× Kanaya, Hiroaki× Kashiwagi, Takashi× Tsunemi, Yasuhiro× Haruna, Shin-ichi |
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著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University | |||||
書誌情報 |
Dokkyo Journal of Medical Sciences 巻 47, 号 3, p. 125-136, 発行日 2020-10-25 |
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要旨(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background:Eosinophilic chronic rhinosinusitis(ECRS) is an intractable subtype of chronic rhinosinusitis(CRS), which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive (MMP-8+)neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS. Methods:Nasal polyps (NPs)in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8+ neutrophils in NPs were evaluated in combination with histological and clinical parameters. Results:MMP-8+ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8+ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group;however, the percentage of MMP-8+ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8+ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8+ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group. Conclusions:This study suggests that MMP-8+ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8+neutrophils might become a candidate of nasal therapeutic target for patients with ECRS. |
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記事種別 | ||||||
値 | Original | |||||
出版者 | ||||||
出版者 | 獨協医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855023 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00629581 |