{"_buckets": {"deposit": "b3c05e28-9849-4b81-ae9b-9da446b7d8ba"}, "_deposit": {"created_by": 14, "id": "2420", "owners": [14], "pid": {"revision_id": 0, "type": "depid", "value": "2420"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00002420", "sets": ["189"]}, "author_link": ["10821", "1619", "10820", "10819", "10818"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-10-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "136", "bibliographicPageStart": "125", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Dokkyo Journal of Medical Sciences"}]}]}, "item_10001_description_35": {"attribute_name": "要旨(英)", "attribute_value_mlt": [{"subitem_description": "Background：Eosinophilic chronic rhinosinusitis（ECRS） is an intractable subtype of chronic rhinosinusitis（CRS）, which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive （MMP-8＋）neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS.\nMethods：Nasal polyps （NPs）in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8＋ neutrophils in NPs were evaluated in combination with histological and clinical parameters.\nResults：MMP-8＋ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8＋ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group；however, the percentage of MMP-8＋ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8＋ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8＋ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group.\nConclusions：This study suggests that MMP-8＋ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8＋neutrophils might become a candidate of nasal therapeutic target for patients with ECRS.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "獨協医学会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"}]}, "item_10001_text_33": {"attribute_name": "記事種別", "attribute_value_mlt": [{"subitem_text_value": "Original"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Akutsu, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanaya, Hiroaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1619", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kashiwagi, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10819", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsunemi, Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haruna, Shin-ichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10821", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-01-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DJMS-47-3-3.pdf", "filesize": [{"value": "337.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 337300.0, "url": {"label": "DJMS-47-3-Akutsu-本文", "url": "https://dmu.repo.nii.ac.jp/record/2420/files/DJMS-47-3-3.pdf"}, "version_id": "dc7c04ae-abe5-424b-a4dc-681511f6a0e2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Tissue remodeling", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Histopathology", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Computed tomography score", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Polyp score", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Olfaction recognition threshold", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study"}]}, "item_type_id": "10001", "owner": "14", "path": ["189"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/2420", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-01-06"}, "publish_date": "2021-01-06", "publish_status": "0", "recid": "2420", "relation": {}, "relation_version_is_last": true, "title": ["Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study"], "weko_shared_id": -1}