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  1. Dokkyo Journal of Medical Sciences
  2. 47(3) 2020

Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis :a Clinico-pathological Study

https://dmu.repo.nii.ac.jp/records/2420
https://dmu.repo.nii.ac.jp/records/2420
e270ba9a-93f8-4a12-8bf1-b4d83684d4d3
名前 / ファイル ライセンス アクション
DJMS-47-3-3.pdf DJMS-47-3-Akutsu-本文 (337.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis :a Clinico-pathological Study
言語
言語 eng
キーワード
主題Scheme Other
主題 Tissue remodeling
キーワード
主題Scheme Other
主題 Histopathology
キーワード
主題Scheme Other
主題 Computed tomography score
キーワード
主題Scheme Other
主題 Polyp score
キーワード
主題Scheme Other
主題 Olfaction recognition threshold
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Akutsu, Makoto

× Akutsu, Makoto

en Akutsu, Makoto

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Kanaya, Hiroaki

× Kanaya, Hiroaki

en Kanaya, Hiroaki

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Kashiwagi, Takashi

× Kashiwagi, Takashi

en Kashiwagi, Takashi

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Tsunemi, Yasuhiro

× Tsunemi, Yasuhiro

en Tsunemi, Yasuhiro

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Haruna, Shin-ichi

× Haruna, Shin-ichi

en Haruna, Shin-ichi

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著者所属(英)
en
Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University
著者所属(英)
en
Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University
著者所属(英)
en
Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University
著者所属(英)
en
Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University
著者所属(英)
en
Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University
書誌情報 Dokkyo Journal of Medical Sciences

巻 47, 号 3, p. 125-136, 発行日 2020-10-25
要旨(英)
内容記述タイプ Other
内容記述 Background:Eosinophilic chronic rhinosinusitis(ECRS) is an intractable subtype of chronic rhinosinusitis(CRS), which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive (MMP-8+)neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS.
Methods:Nasal polyps (NPs)in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8+ neutrophils in NPs were evaluated in combination with histological and clinical parameters.
Results:MMP-8+ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8+ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group;however, the percentage of MMP-8+ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8+ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8+ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group.
Conclusions:This study suggests that MMP-8+ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8+neutrophils might become a candidate of nasal therapeutic target for patients with ECRS.
記事種別
Original
出版者
出版者 獨協医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00629581
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