{"_buckets": {"deposit": "fbd632ad-2b58-49c5-80ed-59f8dcc44fa3"}, "_deposit": {"created_by": 3, "id": "765", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "765"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000765", "sets": ["49"]}, "author_link": ["3189"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "62", "bibliographicPageStart": "T55", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "近年強皮症の皮膚硬化に対するPUVA 療法(8-methoxypsoralen(8-MOP)投与後,長波長紫外線(UVA)を照射する方法)の有効性が数多く報告されているが,この治療による皮膚硬化改善のメカニズムは不明である.我々は正常および強皮症患者真皮由来培養線維芽細胞のI型,III型コラーゲン合成能とコラゲナーゼ遺伝子発現に対する8-methoxypsoralen(8-MOP)存在下UVA 照射の効果を検討した.8-MOP存在下UVA照射は正常人および強皮症患者線維芽細胞ともにI 型,III 型コラーゲン合成とこれらのmRNA レベルをUVA照射量依存性に減少させ,一方でコラゲナーゼ遺伝子発現は不変のままであった.コラーゲン合成の抑制が皮膚硬化に対するPUVA 療法の有効性のメカニズムの1つであることが示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "19", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00006358680", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "学位申請論文", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学皮膚科学"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "8-methoxypsoralen ソンザイカ UVA ショウシャ ノ セイジョウ オヨビ キョウヒショウ センイ ガサイボウ ノ Iガタ, IIIガタ コラーゲン ゴウセイ ノウ ニ タイスル コウカ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "北村, 洋平"}, {"creatorName": "キタムラ, ヨウヘイ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "3189", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006358680.pdf", "filesize": [{"value": "379.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 379000.0, "url": {"label": "KJ00006358680.pdf", "url": "https://dmu.repo.nii.ac.jp/record/765/files/KJ00006358680.pdf"}, "version_id": "d4153a43-4672-48f6-9d1b-d4896b762604"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "UVA 照射", "subitem_subject_scheme": "Other"}, {"subitem_subject": "8-methoxypsoralen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "コラーゲン合成", "subitem_subject_scheme": "Other"}, {"subitem_subject": "強皮症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "線維芽細胞", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "8-methoxypsoralen存在下UVA照射の正常および強皮症線維芽細胞のI 型,III型コラーゲン合成能に対する効果", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "8-methoxypsoralen存在下UVA照射の正常および強皮症線維芽細胞のI 型,III型コラーゲン合成能に対する効果"}]}, "item_type_id": "2", "owner": "3", "path": ["49"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/765", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "765", "relation": {}, "relation_version_is_last": true, "title": ["8-methoxypsoralen存在下UVA照射の正常および強皮症線維芽細胞のI 型,III型コラーゲン合成能に対する効果"], "weko_shared_id": 3}