{"_buckets": {"deposit": "21f61efd-6c05-4a50-b52b-7a8d28f94f65"}, "_deposit": {"created_by": 3, "id": "832", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "832"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000832", "sets": ["53"]}, "author_link": ["3580"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "T17", "bibliographicPageStart": "T11", "bibliographicVolumeNumber": "37", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "横紋筋細胞におけるピオグリタゾンとメトホルミンの単独,及び併用投与時の遺伝子変化について解析した.最初に,ヒト横紋筋由来のA673細胞に対して,1 mMのメトホルミンと10 m Mのピオグリタゾンの単独投与群と両剤併用群を作成し一日培養後,各群にマイクロアレイを施行した.対照と比較し,単独及び,併用投与時には1000個を超える遺伝子で2倍以上の発現を認めた.単独投与で発現が増加し,併用で更に増加した遺伝子群を抽出して階層型クラスター解析と優位機能Pathway解析を施行したところ,階層型クラスター解析では,単独時と比較して,併用時で有意なミトコンドリアb 酸化回路の活性化を認めた(p\u003c0.05).また優位機能Pathway解析では,CPT-1A を含むb 酸化関連遺伝子の活性化を認めた.本研究において,両剤の併用は横紋筋細胞のb 酸化回路を賦活化して,より脂肪燃焼・抗肥満的に作用する可能性が示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "10", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00006373219", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "学位申請論文", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "メトホルミン ト ピオグリタゾン ノ ヘイヨウ ニヨル ヒト バイヨウ オウモンキン サイボウ ニ オケル イデンシ ヘンカ ノ カイセキ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "清水, 裕晶"}, {"creatorName": "シミズ, ヒロアキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "3580", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006373219.pdf", "filesize": [{"value": "535.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 535500.0, "url": {"label": "KJ00006373219.pdf", "url": "https://dmu.repo.nii.ac.jp/record/832/files/KJ00006373219.pdf"}, "version_id": "53e0b9f0-ca98-4f6e-aad8-2781b4dd6e65"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "糖尿病", "subitem_subject_scheme": "Other"}, {"subitem_subject": "横紋筋細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ピオグリタゾン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "メトホルミン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNAマイクロアレイ", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "メトホルミンとピオグリタゾンの併用によるヒト培養 横紋筋細胞における遺伝子変化の解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "メトホルミンとピオグリタゾンの併用によるヒト培養 横紋筋細胞における遺伝子変化の解析"}]}, "item_type_id": "2", "owner": "3", "path": ["53"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/832", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "832", "relation": {}, "relation_version_is_last": true, "title": ["メトホルミンとピオグリタゾンの併用によるヒト培養 横紋筋細胞における遺伝子変化の解析"], "weko_shared_id": 3}