{"_buckets": {"deposit": "ee2f1017-5674-4077-8453-ea17a09b1c92"}, "_deposit": {"created_by": 3, "id": "424", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "424"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000424", "sets": ["37"]}, "author_link": ["1712", "1711"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "69", "bibliographicPageStart": "61", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "術後痛における神経成長因子(NGF)とロイコトリエンB4(LTB4)の役割を調べるために,Brennanの術後痛ラットモデルを用いて,足底部の皮膚切開部位にNGF,LTB4,抗NGF抗体,LTB4受容体括抗薬であるONO4057を投与して,その疼痛閾値に対する効果をvon Frey testで検討した.結果はNGFとLTB4投与で術後痛は変化しなかったが,抗NGF抗体とONO4057投与により術後痛は有意に減少した.よって抗NGF抗体とONO4057は,術後痛を抑制する可能性が示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "To examine the role of nerve growth factor (NGF) and leukotoriene B4 (LTB4) in postoperative pain, we examined whether a Peripherally administered NGF, LTB4, anti-NGF and anti-LTB4 would be the effect for incision-induced mechanical hyperalgesia. We used a rat model of postoperative pain introduced by Brennan et al. Rats underwent a plantar incision, and responses to mechanical stimuli was measured using von Frey filaments. Rats were tested 1 and 96 H after the skin incision. Anti-NGF and anti-LTB4 significantly decreased the response frequencies to mechanical stimulation, however, NGF and LTB4 did not evoke mechanical hyperalgesia. We conclude that anti-NGF and anti-LTB4 can inhibit the mechanical hyperalgesia induced by a surgical incision.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "10", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00004451273", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学越谷病院 麻酔科"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Anesthesiology, Koshigaya hospital, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "ジュツゴツウ ラット モデル ニオケル シンケイ セイチョウ インシ ト ロイコトリエンB4 ノ サヨウ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "久野, 裕一郎"}, {"creatorName": "クノ, ユウイチロウ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1711", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuno, Yuichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1712", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004451273.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "KJ00004451273.pdf", "url": "https://dmu.repo.nii.ac.jp/record/424/files/KJ00004451273.pdf"}, "version_id": "97b8f7b3-ad48-41f8-953b-0c876b02ee33"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "神経成長因子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ロイコトリエンB4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "術後痛", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nerve growth factor (NGF)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LeukotorieneB4 (LTB4)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Postoperative pain", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用"}, {"subitem_title": "The Effect of Nerve Growth Factor and LeukotorienB4 in a Rat Model of Postoperative Pain", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["37"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/424", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "424", "relation": {}, "relation_version_is_last": true, "title": ["術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用"], "weko_shared_id": 3}