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術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用
https://dmu.repo.nii.ac.jp/records/424
https://dmu.repo.nii.ac.jp/records/42421719ccb-2d3a-48a5-9265-b9b8186882ec
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
タイトル | 術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Effect of Nerve Growth Factor and LeukotorienB4 in a Rat Model of Postoperative Pain | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 神経成長因子 | |||||
キーワード | ||||||
主題 | ロイコトリエンB4 | |||||
キーワード | ||||||
主題 | 術後痛 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Nerve growth factor (NGF) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | LeukotorieneB4 (LTB4) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Postoperative pain | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | ジュツゴツウ ラット モデル ニオケル シンケイ セイチョウ インシ ト ロイコトリエンB4 ノ サヨウ | |||||
著者 |
久野, 裕一郎
× 久野, 裕一郎× Kuno, Yuichiro |
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著者所属(日) | ||||||
獨協医科大学越谷病院 麻酔科 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Anesthesiology, Koshigaya hospital, Dokkyo University School of Medicine | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 術後痛における神経成長因子(NGF)とロイコトリエンB4(LTB4)の役割を調べるために,Brennanの術後痛ラットモデルを用いて,足底部の皮膚切開部位にNGF,LTB4,抗NGF抗体,LTB4受容体括抗薬であるONO4057を投与して,その疼痛閾値に対する効果をvon Frey testで検討した.結果はNGFとLTB4投与で術後痛は変化しなかったが,抗NGF抗体とONO4057投与により術後痛は有意に減少した.よって抗NGF抗体とONO4057は,術後痛を抑制する可能性が示唆された. | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | To examine the role of nerve growth factor (NGF) and leukotoriene B4 (LTB4) in postoperative pain, we examined whether a Peripherally administered NGF, LTB4, anti-NGF and anti-LTB4 would be the effect for incision-induced mechanical hyperalgesia. We used a rat model of postoperative pain introduced by Brennan et al. Rats underwent a plantar incision, and responses to mechanical stimuli was measured using von Frey filaments. Rats were tested 1 and 96 H after the skin incision. Anti-NGF and anti-LTB4 significantly decreased the response frequencies to mechanical stimulation, however, NGF and LTB4 did not evoke mechanical hyperalgesia. We conclude that anti-NGF and anti-LTB4 can inhibit the mechanical hyperalgesia induced by a surgical incision. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 33, 号 1, p. 61-69, 発行日 2006-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |